Biosynthesis of prostaglandins

Factors regulating the biosynthesis of various prostaglandins.

the Karolinska Institute working in collaboration with Professor B. Samuelsson. At that time we were able to develop thin-layer techniques which allowed quantitative measurement of the many different products appearing during prostaglandin biosynthesis. This led to the identification of the unusual pros t ag land in , l l -ke to -PGFl , , f rom reaction mixtures(Granstr8m et a1,1968),and a reco...

Biosynthesis of prostaglandins from arachidonic acid in guinea pig lung. Prostaglandins and related factors. 38.

The prostaglandins constitute a class of physiologically active compounds with a widespread occurrence in animal tissues (see References 2 and 3). Previous studies have led to the determination of their structures (4-S), and more recent investigations have shown that they can be formed enzymatically from the essential fatty acids (7,8). It was thus shown that in homogenates of vesicular glands ...

Biosynthesis of Prostaglandins from Arachidonic Acid in Guinea Pig Lung

The prostaglandins constitute a class of physiologically active compounds with a widespread occurrence in animal tissues (see References 2 and 3). Previous studies have led to the determination of their structures (4-S), and more recent investigations have shown that they can be formed enzymatically from the essential fatty acids (7,8). It was thus shown that in homogenates of vesicular glands ...

Pulmonary biosynthesis and metabolism of prostaglandins and related substances.

On passage through the lung vascular bed, prostaglandins are removed from the circulation by a transport carrier and subsequently inactivated by intracellular enzymes. However, PGI2 is not inactivated by the lung in vivo. Although PGI2 is an excellent substrate for the intracellular enzymes in vitro, PGI2 is not a substrate for the carrier system. Thus, the transport carrier determines which ci...

Introduction to the biosynthesis and metabolism of prostaglandins.